Any feedback?
Literature summary for 3.2.1.143 extracted from
- Poly(ADP-ribose) glycohydrolase silencing protects against H2O2-induced cell death (2006), Biochem. J., 396, 419-429.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | enzyme knockout mutation is lethal. Silencing by RNA interference results in 10% of enzyme protein that are sufficient to ensure normal proliferation through several subculturing rounds and cells that are able to repair DNA damage induced by sublethal doses of H2O2. Silenced cells are more resistant than wild-type to oxidant-induced apoptosis while exhibiting delayed poly(ADP-ribose) degradation and transient accumulation of ADP-ribose polymers | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
