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Literature summary for 3.2.1.143 extracted from

  • Abe, H.; Tanuma, S.
    Properties of poly(ADP-ribose) glycohydrolase purified from pig testis nuclei (1996), Arch. Biochem. Biophys., 336, 139-146.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
KCl 200 mM or more Sus scrofa
NaCl 200 mM or more Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0054
-
(ADP-D-ribose)15
-
Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Sus scrofa 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
KCl 50-100 mM, stimulates Sus scrofa
NaCl 50-100 mM, stimulates Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
51000
-
gel filtration Sus scrofa
58000
-
1 * 58000, SDS-PAGE Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
32.1
-
-
Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(ADP-D-ribose)15 + H2O
-
Sus scrofa (ADP-ribose)14 + ADP-D-ribose
-
?
poly(ADP-ribose)n + H2O
-
Sus scrofa ADP-ribose
-
?

Subunits

Subunits Comment Organism
monomer 1 * 58000, SDS-PAGE Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
-
Sus scrofa

pH Range

pH Minimum pH Maximum Comment Organism
6 8.5 pH 6.0: about 50% of maximal activity, pH 8.5: about 35% of maximal activity Sus scrofa