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Literature summary for 3.2.1.143 extracted from

  • Sugimura, T.; Yamada, M.; Miwa, M.; Matsushima, T.; Hidaka, T.; Nagao, M.; Inui, N.; Takayama, S.
    Properties of poly(adenosine diphosphate ribose) polymerase, poly(adenosine diphosphate ribose) glycohydrolase and poly(adenosine diphosphate ribose) (1973), Biochem. Soc. Trans., 1, 642-644.
No PubMed abstract available
Search for more literature for 3.2.1.143

Activating Compound

Activating Compound Comment Organism Structure
2-mercaptoethanol enhances activity Bos taurus
dithiothreitol enhances activity Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
adenosine 3':5'-cyclic monophosphate
-
 Bos taurus
adenosine cyclic 2':3'-monophosphate
-
 Bos taurus
ADP
-
 Bos taurus
ADP-ribose
-
 Bos taurus
AMP
-
 Bos taurus
ATP
-
 Bos taurus
guanosine cyclic 3':5'-monophosphate
-
 Bos taurus
histone lysine-rich histone of calf thymus Bos taurus
NAD+
-
 Bos taurus
p-chloromercuribenzenesulfonate
-
 Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
poly(ADP-ribose)n + H2O Bos taurus the enzyme may regulate functionally the chain length of poly(ADP-ribose) which plays a role in DNA synthesis or in the structure of chromatin ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
 calf
-

Source Tissue

Source Tissue Comment Organism Textmining
thymus
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
poly(ADP-ribose)n + H2O
-
 Bos taurus ADP-ribose
-
 ?
poly(ADP-ribose)n + H2O the enzyme may regulate functionally the chain length of poly(ADP-ribose) which plays a role in DNA synthesis or in the structure of chromatin Bos taurus ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
 Bos taurus