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Literature summary for 3.2.1.14 extracted from

  • Seibold, M.A.; Reese, T.A.; Choudhry, S.; Salam, M.T.; Beckman, K.; Eng, C.; Atakilit, A.; Meade, K.; Lenoir, M.; Watson, H.G.; Thyne, S.; Kumar, R.; Weiss, K.B.; Grammer, L.C.; Avila, P.; Schleimer, R.P.; Fahy, J.V.; Rodriguez-Santana, J.; Rodriguez-Cintron, W.; Boot, R.G.; Sheppard, D.; Gilliland, F.D.; et al.
    Differential enzymatic activity of common haplotypic versions of the human acidic mammalian chitinase protein (2009), J. Biol. Chem., 284, 19650-19658.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine resequencing of all 12 AMCase exons in three diverse populations: African Americans, Puerto Ricans, and Mexicans leads to identification of 21 variants including four 5-untranslated region variants, nine non-synonymous single nucleotide polymorphisms, four synonymous single nucleotide polymorphisms, a 3-untranslated region single nucleotide polymorphism, and three intronic single nucleotide polymorphisms. Among the non-synonymous single nucleotide polymorphisms eight variants are common to all three racial groups single nucleotide polymorphisms: A290G, N45D, G296A, D47N, G339T, R61M, G461A, G102R, A531G, K125R, G1172A, V339I, T1218C, F354S, and G1452T, G432V. Minimal linkage disequilibrium is exhibited between these variants with the exception of single nucleotide polymorphisms A290G, G296A, and G339T. The G339T single nucelotide polymorphism is associated with asthma protection in some populations Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
three-dimensional modeling of variant isoforms. The overall protein fold is not altered in mutant N45D/D47N/R61M Homo sapiens

Protein Variants

Protein Variants Comment Organism
N45D/D47N/R61M natural mutant based on single nucleotide polymorphisms. The mutant is 4-, 2.5-, and 10fold more active than the wild type AMCase isoform at pH 2.2, 4.6, and 7.0, respectively Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.03
-
4-methylumbelliferyl 2-acetamido-4-O-(2-acetamido-2,4-dideoxy-beta-D-xylo-hexopyranosyl)-2-deoxy-beta-D-glucopyranoside mutant N45D/D47N/R61M, pH 4.6, 37°C Homo sapiens
0.048
-
4-methylumbelliferyl 2-acetamido-4-O-(2-acetamido-2,4-dideoxy-beta-D-xylo-hexopyranosyl)-2-deoxy-beta-D-glucopyranoside mutant N45D/D47N/R61M, pH 2.2, 37°C Homo sapiens
0.07
-
4-methylumbelliferyl 2-acetamido-4-O-(2-acetamido-2,4-dideoxy-beta-D-xylo-hexopyranosyl)-2-deoxy-beta-D-glucopyranoside wild-type, pH 4.6, 37°C Homo sapiens
0.072
-
4-methylumbelliferyl 2-acetamido-4-O-(2-acetamido-2,4-dideoxy-beta-D-xylo-hexopyranosyl)-2-deoxy-beta-D-glucopyranoside mutant N45D/D47N/R61M, pH 7.0, 37°C Homo sapiens
0.134
-
4-methylumbelliferyl 2-acetamido-4-O-(2-acetamido-2,4-dideoxy-beta-D-xylo-hexopyranosyl)-2-deoxy-beta-D-glucopyranoside wild-type, pH 7.0, 37°C Homo sapiens
0.171
-
4-methylumbelliferyl 2-acetamido-4-O-(2-acetamido-2,4-dideoxy-beta-D-xylo-hexopyranosyl)-2-deoxy-beta-D-glucopyranoside wild-type, pH 2.2, 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BZP6
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-methylumbelliferyl 2-acetamido-4-O-(2-acetamido-2,4-dideoxy-beta-D-xylo-hexopyranosyl)-2-deoxy-beta-D-glucopyranoside + H2O
-
Homo sapiens 4-methylumbelliferol + 2-acetamido-4-O-(2-acetamido-2,4-dideoxy-beta-D-xylo-hexopyranosyl)-2-deoxy-beta-D-glucopyranoside
-
?

Synonyms

Synonyms Comment Organism
AMCase
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.05
-
4-methylumbelliferyl 2-acetamido-4-O-(2-acetamido-2,4-dideoxy-beta-D-xylo-hexopyranosyl)-2-deoxy-beta-D-glucopyranoside wild-type, pH 7.0, 37°C Homo sapiens
0.34
-
4-methylumbelliferyl 2-acetamido-4-O-(2-acetamido-2,4-dideoxy-beta-D-xylo-hexopyranosyl)-2-deoxy-beta-D-glucopyranoside wild-type, pH 2.2, 37°C Homo sapiens
0.56
-
4-methylumbelliferyl 2-acetamido-4-O-(2-acetamido-2,4-dideoxy-beta-D-xylo-hexopyranosyl)-2-deoxy-beta-D-glucopyranoside mutant N45D/D47N/R61M, pH 7.0, 37°C Homo sapiens
0.713
-
4-methylumbelliferyl 2-acetamido-4-O-(2-acetamido-2,4-dideoxy-beta-D-xylo-hexopyranosyl)-2-deoxy-beta-D-glucopyranoside wild-type, pH 4.6, 37°C Homo sapiens
1.43
-
4-methylumbelliferyl 2-acetamido-4-O-(2-acetamido-2,4-dideoxy-beta-D-xylo-hexopyranosyl)-2-deoxy-beta-D-glucopyranoside mutant N45D/D47N/R61M, pH 2.2, 37°C Homo sapiens
1.83
-
4-methylumbelliferyl 2-acetamido-4-O-(2-acetamido-2,4-dideoxy-beta-D-xylo-hexopyranosyl)-2-deoxy-beta-D-glucopyranoside mutant N45D/D47N/R61M, pH 4.6, 37°C Homo sapiens