Application | Comment | Organism |
---|---|---|
medicine | resequencing of all 12 AMCase exons in three diverse populations: African Americans, Puerto Ricans, and Mexicans leads to identification of 21 variants including four 5-untranslated region variants, nine non-synonymous single nucleotide polymorphisms, four synonymous single nucleotide polymorphisms, a 3-untranslated region single nucleotide polymorphism, and three intronic single nucleotide polymorphisms. Among the non-synonymous single nucleotide polymorphisms eight variants are common to all three racial groups single nucleotide polymorphisms: A290G, N45D, G296A, D47N, G339T, R61M, G461A, G102R, A531G, K125R, G1172A, V339I, T1218C, F354S, and G1452T, G432V. Minimal linkage disequilibrium is exhibited between these variants with the exception of single nucleotide polymorphisms A290G, G296A, and G339T. The G339T single nucelotide polymorphism is associated with asthma protection in some populations | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
three-dimensional modeling of variant isoforms. The overall protein fold is not altered in mutant N45D/D47N/R61M | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
N45D/D47N/R61M | natural mutant based on single nucleotide polymorphisms. The mutant is 4-, 2.5-, and 10fold more active than the wild type AMCase isoform at pH 2.2, 4.6, and 7.0, respectively | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.03 | - |
4-methylumbelliferyl 2-acetamido-4-O-(2-acetamido-2,4-dideoxy-beta-D-xylo-hexopyranosyl)-2-deoxy-beta-D-glucopyranoside | mutant N45D/D47N/R61M, pH 4.6, 37°C | Homo sapiens | |
0.048 | - |
4-methylumbelliferyl 2-acetamido-4-O-(2-acetamido-2,4-dideoxy-beta-D-xylo-hexopyranosyl)-2-deoxy-beta-D-glucopyranoside | mutant N45D/D47N/R61M, pH 2.2, 37°C | Homo sapiens | |
0.07 | - |
4-methylumbelliferyl 2-acetamido-4-O-(2-acetamido-2,4-dideoxy-beta-D-xylo-hexopyranosyl)-2-deoxy-beta-D-glucopyranoside | wild-type, pH 4.6, 37°C | Homo sapiens | |
0.072 | - |
4-methylumbelliferyl 2-acetamido-4-O-(2-acetamido-2,4-dideoxy-beta-D-xylo-hexopyranosyl)-2-deoxy-beta-D-glucopyranoside | mutant N45D/D47N/R61M, pH 7.0, 37°C | Homo sapiens | |
0.134 | - |
4-methylumbelliferyl 2-acetamido-4-O-(2-acetamido-2,4-dideoxy-beta-D-xylo-hexopyranosyl)-2-deoxy-beta-D-glucopyranoside | wild-type, pH 7.0, 37°C | Homo sapiens | |
0.171 | - |
4-methylumbelliferyl 2-acetamido-4-O-(2-acetamido-2,4-dideoxy-beta-D-xylo-hexopyranosyl)-2-deoxy-beta-D-glucopyranoside | wild-type, pH 2.2, 37°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9BZP6 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-methylumbelliferyl 2-acetamido-4-O-(2-acetamido-2,4-dideoxy-beta-D-xylo-hexopyranosyl)-2-deoxy-beta-D-glucopyranoside + H2O | - |
Homo sapiens | 4-methylumbelliferol + 2-acetamido-4-O-(2-acetamido-2,4-dideoxy-beta-D-xylo-hexopyranosyl)-2-deoxy-beta-D-glucopyranoside | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AMCase | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.05 | - |
4-methylumbelliferyl 2-acetamido-4-O-(2-acetamido-2,4-dideoxy-beta-D-xylo-hexopyranosyl)-2-deoxy-beta-D-glucopyranoside | wild-type, pH 7.0, 37°C | Homo sapiens | |
0.34 | - |
4-methylumbelliferyl 2-acetamido-4-O-(2-acetamido-2,4-dideoxy-beta-D-xylo-hexopyranosyl)-2-deoxy-beta-D-glucopyranoside | wild-type, pH 2.2, 37°C | Homo sapiens | |
0.56 | - |
4-methylumbelliferyl 2-acetamido-4-O-(2-acetamido-2,4-dideoxy-beta-D-xylo-hexopyranosyl)-2-deoxy-beta-D-glucopyranoside | mutant N45D/D47N/R61M, pH 7.0, 37°C | Homo sapiens | |
0.713 | - |
4-methylumbelliferyl 2-acetamido-4-O-(2-acetamido-2,4-dideoxy-beta-D-xylo-hexopyranosyl)-2-deoxy-beta-D-glucopyranoside | wild-type, pH 4.6, 37°C | Homo sapiens | |
1.43 | - |
4-methylumbelliferyl 2-acetamido-4-O-(2-acetamido-2,4-dideoxy-beta-D-xylo-hexopyranosyl)-2-deoxy-beta-D-glucopyranoside | mutant N45D/D47N/R61M, pH 2.2, 37°C | Homo sapiens | |
1.83 | - |
4-methylumbelliferyl 2-acetamido-4-O-(2-acetamido-2,4-dideoxy-beta-D-xylo-hexopyranosyl)-2-deoxy-beta-D-glucopyranoside | mutant N45D/D47N/R61M, pH 4.6, 37°C | Homo sapiens |