Application | Comment | Organism |
---|---|---|
pharmacology | hAMCase is a potential therapeutic target for anti-inflammatory therapy in Th2-mediated diseases such as asthma | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
allosamidin | modelling of ligand binding at the active site, Glu119 forms hydrogen bond with allosamidin. Trp10, Glu49, Asp192, and Glu276 in hAMCase are four important determinant residues in binding as they form strong van der Waals and electrostatic interactions with the ligand, respectively | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9BZP6 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung | - |
Homo sapiens | - |
stomach | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | modelling of (GlcNAc)2 ligand binding at the active site | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | three-dimensional structure modelling using the crystal structure of the human chitotriosidase, EC 3.2.1.44, PDB ID 1HKK, and the molecular mechanics and molecular dynamics methods, overview | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
acidic mammalian chitinase | - |
Homo sapiens |
AMCase | - |
Homo sapiens |