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Literature summary for 3.2.1.14 extracted from

  • Kzhyshkowska, J.; Mamidi, S.; Gratchev, A.; Kremmer, E.; Schmuttermaier, C.; Krusell, L.; Haus, G.; Utikai, J.; Schledzewski, K.; Scholtze, J.; Goerdt, S.
    Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway (2006), Blood, 107, 3221-3228.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information dexamethasone, cytokine Th2 and interleukin IL-4 strongly up-regulate SI-CLP in macrophages, the effect is suppressed by IFNgamma but not by IL-10 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
stable expression of SI-CLP in H1299 cells, SI-CLP expression analysis in human cell lines, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endosome late Homo sapiens 5768
-
extracellular the enzyme is secreted via lysosomal pathway Homo sapiens
-
-
lysosome secretory Homo sapiens 5764
-
additional information SI-CLP expression analysis, colocalization of SI-CLP with stabilin-1 in the trans Golgi network Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bronchus in bronchoalveolar lavage Homo sapiens
-
epithelium
-
Homo sapiens
-
leukocyte peripheral Homo sapiens
-
lung
-
Homo sapiens
-
macrophage alternatively activated, lysosomes and endosomes Homo sapiens
-
additional information expression in human cell lines, overview Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information SI-CLP shows no chitinase due to the lack of chitin-binding domain, but cytokine activity, the enzyme directly interacts with stabilin-1, which is involved in intracellular sorting of SI-CLP Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
? x * 39000-43000, SI-CLP, SDS-PAGE Homo sapiens
More SI-CLP is lacking the chitin-binding domain Homo sapiens

Synonyms

Synonyms Comment Organism
More SI-CLP is a glyco_18_domain-containing protein Homo sapiens
SI-CLP
-
Homo sapiens
stabilin-1 interacting chitinase-like protein
-
Homo sapiens