Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | dexamethasone, cytokine Th2 and interleukin IL-4 strongly up-regulate SI-CLP in macrophages, the effect is suppressed by IFNgamma but not by IL-10 | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
stable expression of SI-CLP in H1299 cells, SI-CLP expression analysis in human cell lines, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endosome | late | Homo sapiens | 5768 | - |
extracellular | the enzyme is secreted via lysosomal pathway | Homo sapiens | - |
- |
lysosome | secretory | Homo sapiens | 5764 | - |
additional information | SI-CLP expression analysis, colocalization of SI-CLP with stabilin-1 in the trans Golgi network | Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bronchus | in bronchoalveolar lavage | Homo sapiens | - |
epithelium | - |
Homo sapiens | - |
leukocyte | peripheral | Homo sapiens | - |
lung | - |
Homo sapiens | - |
macrophage | alternatively activated, lysosomes and endosomes | Homo sapiens | - |
additional information | expression in human cell lines, overview | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | SI-CLP shows no chitinase due to the lack of chitin-binding domain, but cytokine activity, the enzyme directly interacts with stabilin-1, which is involved in intracellular sorting of SI-CLP | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 39000-43000, SI-CLP, SDS-PAGE | Homo sapiens |
More | SI-CLP is lacking the chitin-binding domain | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
More | SI-CLP is a glyco_18_domain-containing protein | Homo sapiens |
SI-CLP | - |
Homo sapiens |
stabilin-1 interacting chitinase-like protein | - |
Homo sapiens |