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Literature summary for 3.2.1.130 extracted from
- Immunohistochemical evaluation of endomannosidase distribution in rat tissues: evidence for cell type-specific expression (2000), Histochem. Cell Biol., 114, 461-467.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli JM109 | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Rattus norvegicus | 5783 | - |
| Golgi apparatus | - |
Rattus norvegicus | 5794 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 56000 | - |
SDS-PAGE | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GlcMan9GlcNAc + H2O | Rattus norvegicus | only processing enzyme which cleaves internally and provides an alternate deglucosylation pathway | Man8GlcNAc + glucosyl alpha1,3-mannose | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| no activity in Cricetulus griseus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant protein, expressed in Escherichia coli | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| colon | surface epithelium and crypt epithelium | Rattus norvegicus | - |
| hepatocyte | - |
Rattus norvegicus | - |
| jejunum | villus epithelium and crypt epithelium | Rattus norvegicus | - |
| kidney | distal and collecting tubules, no activity in proximal tubules | Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
| additional information | endothelial cells are unreactive for endomannosidase, no activity in stomach mucosa, adrenal cortex and medulla, and testis sertoli cells | Rattus norvegicus | - |
| neuron | - |
Rattus norvegicus | - |
| pancreas | acinar cells | Rattus norvegicus | - |
| testis | seminiferous tubules and Leydig cells | Rattus norvegicus | - |
| thyroid gland | follicular cells | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Glc3Man9GlcNAc2 + H2O | - |
Rattus norvegicus | ? | - |
? | |
| GlcMan9GlcNAc + H2O | - |
Rattus norvegicus | Man8GlcNAc + glucosyl alpha1,3-mannose | cleaves internally between the glucose-substituted mannose and the remaining oligosaccharide to release a Glcalpha1,3Man disaccharide | ? | |
| GlcMan9GlcNAc + H2O | only processing enzyme which cleaves internally and provides an alternate deglucosylation pathway | Rattus norvegicus | Man8GlcNAc + glucosyl alpha1,3-mannose | - |
? | |
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Release 2023.1 (January 2023)
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