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Literature summary for 3.2.1.129 extracted from

  • Pekcec, A.; Fuest, C.; Muehlenhoff, M.; Gerardy-Schahn, R.; Potschka, H.
    Targeting epileptogenesis-associated induction of neurogenesis by enzymatic depolysialylation of NCAM counteracts spatial learning dysfunction but fails to impact epilepsy development (2008), J. Neurochem., 105, 389-400.
    View publication on PubMed

Application

Application Comment Organism
medicine investigation of possible role of polysialic neural cell adhesion molecules in the pathophysiology of epilepsy Escherichia phage K1F
additional information almost complete removal of polysialic acid by endo-N injection into the brain 5 days after stimulation (return to normal polysialic acid levels after 11 weeks): no effect on proliferation, neurogenesis, and the fate of newborn cells in the hippocampus of rats without status epileptics. Increase of newborn cells in status epileptics rats compared to controls without significant difference between endo-N and vehicle treatment. However, endo-N treatment reduces the total number of newborn neurons (64%) upon induction of the status epileptics compared to vehicle treatment. No endo-N effect on hilar basal dendrite generation compared to vehicle control. No effect on doublecortin-expressing neuronal progenitor cells, and no effect on subpopulation of these cells with persistent basal dendrites compared to vehicle control. No difference in number, severity and duration of seizures between groups. Spatial learning deficit of status epilepticus mice is reduced by end-N treatment compared to vehicle control Escherichia phage K1F

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
polysialylated neural cell adhesion molecule + H2O Escherichia phage K1F
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?
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?

Organism

Organism UniProt Comment Textmining
Escherichia phage K1F
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-2,8-linked polysialic acid + H2O
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Escherichia phage K1F ?
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?
polysialylated neural cell adhesion molecule + H2O
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Escherichia phage K1F ?
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?

Synonyms

Synonyms Comment Organism
endoneuraminidase
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Escherichia phage K1F
endoNF from coliphage K1F Escherichia phage K1F
endosialidase
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Escherichia phage K1F