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Literature summary for 3.2.1.114 extracted from

  • Bobovska, A.; Tvaro?ka, I.; Kona, J.
    Using DFT methodology for more reliable predictive models Design of inhibitors of Golgi alpha-mannosidase II (2016), J. Mol. Graph. Model., 66, 47-57 .
    View publication on PubMed

Application

Application Comment Organism
pharmacology the enzyme is a pharmaceutical target for the design of inhibitors with anti-cancer activity. The QSAR models with the fragmented QM-DFT descriptors may find a useful application in structure-based drug design where pure empirical and forcefield methods reach their limits and where quantum mechanics effects are critical for ligand-receptor interactions. The optimized models will apply in lead optimization processes for alpha-mannosidase II drug developments Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
Homo sapiens 5794
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
alpha-mannosidase II
-
Homo sapiens
GmII
-
Homo sapiens