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Literature summary for 3.2.1.114 extracted from

  • Polakova, M.; Sestak, S.; Lattova, E.; Petrus, L.; Mucha, J.; Tvaroska, I.; Kona, J.
    alpha-D-mannose derivatives as models designed for selective inhibition of Golgi alpha-mannosidase II (2011), Eur. J. Med. Chem., 46, 944-952.
    View publication on PubMed
Search for more literature for 3.2.1.114

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Drosophila melanogaster Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(RS)-2-phenylethyl alpha-D-mannopyranosyl sulfoxide
-
 Homo sapiens
2-phenylethyl alpha-D-mannopyranosyl sulfone
-
 Homo sapiens
benzyl alpha-D-mannopyranosyl sulfone
-
 Homo sapiens
Mannostatin A
-
 Homo sapiens
additional information not inhibited by alpha-D-mannose Homo sapiens
swainsonine
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl alpha-D-mannopyranoside + H2O
-
 Homo sapiens 4-nitrophenol + alpha-D-mannopyranose
-
 ?

Synonyms

Synonyms Comment Organism
Golgi alpha-mannosidase II
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000005
-
 in 50 mM sodium acetate buffer pH 5.8, at 37°C Homo sapiens swainsonine
0.00013
-
 in 50 mM sodium acetate buffer pH 5.8, at 37°C Homo sapiens Mannostatin A
1.5
-
 in 50 mM sodium acetate buffer pH 5.8, at 37°C Homo sapiens 2-phenylethyl alpha-D-mannopyranosyl sulfone
2
-
 in 50 mM sodium acetate buffer pH 5.8, at 37°C Homo sapiens benzyl alpha-D-mannopyranosyl sulfone
2.5
-
 in 50 mM sodium acetate buffer pH 5.8, at 37°C Homo sapiens (RS)-2-phenylethyl alpha-D-mannopyranosyl sulfoxide