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Literature summary for 3.2.1.114 extracted from

  • Bello, C.; Cea, M.; Bello, G.D.; Garuti, A.; Rocco, I.; Cirmena, G.; Moran, E.; Nahimana, A.; Duchosal, M.A.; Fruscione, F.; Pronzato, P.; Grossi, F.; Patrone, F.; Ballestrero, A.; Dupuis, M.; Sordat, B.; Nencioni, A.; Vogel, P.
    Novel 2-[(benzylamino)methyl]pyrrolidine-3,4-diol derivatives as alpha-mannosidase inhibitors and with antitumor activities against hematological and solid malignancies (2010), Bioorg. Med. Chem., 18, 3320-3334.
    View publication on PubMed
Search for more literature for 3.2.1.114

Inhibitors

Inhibitors Comment Organism Structure
(2R,3R,4S)-2-[[((1R)-2-hydroxy-1-[4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl]ethyl)amino] methyl]pyrrolidine-3,4-diol inhibits the proliferation of primary cells and cell lines of different origins, irrespective of Bcl-2 expression levels, inducing a G2/Mcell cycle arrest and by modification of genes involved in cell cycle progression and survival, IC50 in vivo and cytotoxic effects in different cell lines, overview Homo sapiens
(2R,3R,4S)-2[([(1R)-2-hydroxy-1-(4-methoxyphenyl)ethyl]amino)-methyl]pyrrolidine-3,4-diol
-
 Homo sapiens
(2R,3R,4S)-2[[((1R)-1-[1,1'-biphenyl]-4-yl-2-hydroxyethyl)amino]-methyl]pyrrolidine-3,4-diol
-
 Homo sapiens
(2R,3R,4S)-2[[((1R)-2-hydroxy-1-(4-(phenylmethoxy)phenyl)ethyl)amino]methyl]pyrrolidine-3,4-diol
-
 Homo sapiens
(2R,3R,4S)-2[[((1R)-2-hydroxy-1-[4-(2-thienyl)phenyl]ethyl)-amino]methyl]pyrrolidine-3,4-diol
-
 Homo sapiens
(2R,3R,4S)-2[[((1R)-2-hydroxy-1-[4-(prop-2-enyloxy)phenyl]-ethyl)amino]methyl] pyrrolidine-3,4-diol
-
 Homo sapiens
additional information inhibitor design and synthesis, and cytototxic effect in vivo, overview. 2-[(Benzylamino)methyl]pyrrolidine-3,4-diol derivatives as alpha-mannosidase inhibitors and with antitumor activities against hematological and solid malignancies Homo sapiens
swainsonine
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
 Homo sapiens 5794
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
BT-474 cell
-
 Homo sapiens
-
JURKAT cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-
PC-3 cell
-
 Homo sapiens
-
SK-BR-3 cell
-
 Homo sapiens
-
U-266 cell
-
 Homo sapiens
-
U-87MG cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
alpha-mannosidase II
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function key enzyme in removal of mannose residues from the maturing oligosaccharide by hydrolyzing the mannosyl glycosidic bond as part of the machinery of complex carbohydrate formation Homo sapiens