Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1R,6R,7R,8S)-7,8-dihydroxy-5-thia-1-thioniabicyclo[4.3.0]nonane chloride | synthetic inhibitor, selective and potent inhibition at 1 mM, 97% inhibition of the activity of the liver lysosomal fraction at pH 4.0, 100% at pH 6.5 | Homo sapiens | |
1-deoxymannojirimycin | 61% inhibition of the activity of the liver lysosomal fraction at pH 4.0, 37% at pH 6.5, at 1 mM | Homo sapiens | |
8,8a-di-epi-swainsonine | - |
Homo sapiens | |
8a-epi-swainsonine | - |
Homo sapiens | |
swainsonine | potent inhibition at 1 mM, 100% inhibition of the activity of the liver lysosomal fraction at pH 4.0, 95% at pH 6.5 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
class II alpha-D-mannosidase | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.02 | - |
8,8a-di-epi-swainsonine | liver lysosomal fraction | Homo sapiens | |
0.75 | - |
8a-epi-swainsonine | liver lysosomal fraction | Homo sapiens | |
0.75 | - |
1-deoxymannojirimycin | pH 5.5, liver lysosomal fraction | Homo sapiens |