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Literature summary for 3.2.1.114 extracted from

  • Siriwardena, A.; Strachan, H.; El-Daher, S.; Way, G.; Winchester, B.; Glushka, J.; Moremen, K.; Boons, G.
    Potent and selective inhibition of class II alpha-D-mannosidase activity by a bicyclic sulfonium salt (2005), ChemBioChem, 6, 845-848.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(1R,6R,7R,8S)-7,8-dihydroxy-5-thia-1-thioniabicyclo[4.3.0]nonane chloride synthetic inhibitor, selective and potent inhibition at 1 mM, 97% inhibition of the activity of the liver lysosomal fraction at pH 4.0, 100% at pH 6.5 Homo sapiens
1-deoxymannojirimycin 61% inhibition of the activity of the liver lysosomal fraction at pH 4.0, 37% at pH 6.5, at 1 mM Homo sapiens
8,8a-di-epi-swainsonine
-
Homo sapiens
8a-epi-swainsonine
-
Homo sapiens
swainsonine potent inhibition at 1 mM, 100% inhibition of the activity of the liver lysosomal fraction at pH 4.0, 95% at pH 6.5 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Homo sapiens 5764
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
class II alpha-D-mannosidase
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.02
-
8,8a-di-epi-swainsonine liver lysosomal fraction Homo sapiens
0.75
-
8a-epi-swainsonine liver lysosomal fraction Homo sapiens
0.75
-
1-deoxymannojirimycin pH 5.5, liver lysosomal fraction Homo sapiens