Inhibitors | Comment | Organism | Structure |
---|---|---|---|
D-mannonolactam amidrazone | broad spectrum mannosidase inhibitor, strong; IC50: 400 nM | Canis lupus familiaris | |
D-mannonolactam amidrazone | broad spectrum mannosidase inhibitor, strong; equally as effective as mannostatin A, IC50: 90-100 nM | Vigna radiata | |
Mannostatin A | cyclopentanol structure containing thiomethyl and amino functional groups, in vivo and in vitro | Canis lupus familiaris | |
Mannostatin A | cyclopentanol structure containing thiomethyl and amino functional groups, in vivo and in vitro; potent inhibitor, equally effective as D-mannonolactam amidrazone | Vigna radiata |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Canis lupus familiaris | asparagine-linked glycoprotein biosynthesis | ? | - |
? | |
additional information | Vigna radiata | asparagine-linked glycoprotein biosynthesis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
- |
- |
Vigna radiata | - |
mung bean | - |
Purification (Comment) | Organism |
---|---|
- |
Vigna radiata |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MDCK cell | influenza virus-infected | Canis lupus familiaris | - |
seedling | - |
Vigna radiata | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GlcNAc(Man)5GlcNAc + 2 H2O | - |
Canis lupus familiaris | GlcNAc(Man)3GlcNAc + 2 alpha-D-mannose | - |
? | |
GlcNAc(Man)5GlcNAc + 2 H2O | - |
Vigna radiata | GlcNAc(Man)3GlcNAc + 2 alpha-D-mannose | - |
? | |
additional information | asparagine-linked glycoprotein biosynthesis | Canis lupus familiaris | ? | - |
? | |
additional information | asparagine-linked glycoprotein biosynthesis | Vigna radiata | ? | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00009 | 0.0001 | equally as effective as mannostatin A, IC50: 90-100 nM | Vigna radiata | D-mannonolactam amidrazone | |
0.0004 | - |
IC50: 400 nM | Canis lupus familiaris | D-mannonolactam amidrazone |