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Literature summary for 3.2.1.114 extracted from

  • Pan, Y.T.; Kaushal, G.P.; Papandreou, G.; Ganem, B.; Elbein, A.D.
    D-Mannonolactam amidrazone. A new mannosidase inhibitor that also inhibits the endoplasmic reticulum or cytoplasmic alpha-mannosidase (1992), J. Biol. Chem., 267, 8313-8318.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
D-mannonolactam amidrazone broad spectrum mannosidase inhibitor, strong; IC50: 400 nM Canis lupus familiaris
D-mannonolactam amidrazone broad spectrum mannosidase inhibitor, strong; equally as effective as mannostatin A, IC50: 90-100 nM Vigna radiata
Mannostatin A cyclopentanol structure containing thiomethyl and amino functional groups, in vivo and in vitro Canis lupus familiaris
Mannostatin A cyclopentanol structure containing thiomethyl and amino functional groups, in vivo and in vitro; potent inhibitor, equally effective as D-mannonolactam amidrazone Vigna radiata

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Canis lupus familiaris asparagine-linked glycoprotein biosynthesis ?
-
?
additional information Vigna radiata asparagine-linked glycoprotein biosynthesis ?
-
?

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
-
-
Vigna radiata
-
mung bean
-

Purification (Commentary)

Purification (Comment) Organism
-
Vigna radiata

Source Tissue

Source Tissue Comment Organism Textmining
MDCK cell influenza virus-infected Canis lupus familiaris
-
seedling
-
Vigna radiata
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GlcNAc(Man)5GlcNAc + 2 H2O
-
Canis lupus familiaris GlcNAc(Man)3GlcNAc + 2 alpha-D-mannose
-
?
GlcNAc(Man)5GlcNAc + 2 H2O
-
Vigna radiata GlcNAc(Man)3GlcNAc + 2 alpha-D-mannose
-
?
additional information asparagine-linked glycoprotein biosynthesis Canis lupus familiaris ?
-
?
additional information asparagine-linked glycoprotein biosynthesis Vigna radiata ?
-
?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00009 0.0001 equally as effective as mannostatin A, IC50: 90-100 nM Vigna radiata D-mannonolactam amidrazone
0.0004
-
IC50: 400 nM Canis lupus familiaris D-mannonolactam amidrazone