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Literature summary for 3.2.1.113 extracted from

  • Pan, Y.T.; Kaushal, G.P.; Papandreou, G.; Ganem, B.; Elbein, A.D.
    D-Mannonolactam amidrazone. A new mannosidase inhibitor that also inhibits the endoplasmic reticulum or cytoplasmic alpha-mannosidase (1992), J. Biol. Chem., 267, 8313-8318 .
    View publication on PubMed
Search for more literature for 3.2.1.113

Inhibitors

Inhibitors Comment Organism Structure
D-mannonolactam amidrazone inhibitor is a mimic of the mannopyranosyl cation and acts as a potent broad spectrum mannosidase inhibitor. In the presence of mannonoamidrazone, most of the oligosaccharides are not processed beyond the high mannose structure Oryctolagus cuniculus
D-mannonolactam amidrazone inhibitor is a mimic of the mannopyranosyl cation and acts as a potent broad spectrum mannosidase inhibitor. It is inactive against processing glucosidases I and II Vigna radiata var. radiata
additional information not inhibitory up to 0.25 mM: mannostatin A Vigna radiata var. radiata

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-
Vigna radiata var. radiata
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MDCK cell
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-alpha-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] + 4 H2O
-
 Vigna radiata var. radiata alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-alpha-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] + 4 beta-D-mannopyranose
-
 ?
alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-alpha-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] + 4 H2O
-
 Oryctolagus cuniculus alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-alpha-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] + 4 beta-D-mannopyranose
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.003
-
 pH not specified in the publication, temperature not specified in the publication Oryctolagus cuniculus D-mannonolactam amidrazone
0.004
-
 pH not specified in the publication, temperature not specified in the publication Vigna radiata var. radiata D-mannonolactam amidrazone