Literature summary for 3.2.1.113 extracted from

Li, H.; Wang, G.; Yu, Y.; Jian, W.; Zhang, D.; Wang, Y.; Wang, T.; Meng, Y.; Yuan, C.; Zhang, C.
alpha-1,2-Mannosidase MAN1C1 inhibits proliferation and invasion of clear cell renal cell carcinoma (2018), J. Cancer, 9, 4618-4626 .

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Application

Application	Comment	Organism
diagnostics	MAN1C1 may be a useful prognostic biomarker and potential therapeutic target in clear cell renal cell carcinoma, with the potential to lead to better outcomes for patients with these poor prognosis malignancies	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
MAN1C1 gene over-expression is used to transfect human renal cancer cell lines 786-O and OS-RC-2	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9NR34	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
renal cell carcinoma cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
MAN1C1	-	Homo sapiens

General Information

General Information	Comment	Organism
metabolism	overexpression MAN1C1 shows anti-tumor effect by inducing apoptosis. MAN1C1 overexpression remarkably increases the ratio of Bax/Bcl-2 and inhibits epithelial-mesenchymal transition by increasing the expression of E-CA. In addition, the ratio of Bax/Bcl-2 and E-cadherin is increased in MAN1C1 gene overexpression renal cancer cells compared with the control cells	Homo sapiens

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Release 2023.1 (January 2023)