Inhibitors | Comment | Organism | Structure |
---|---|---|---|
deoxymannojirimycin | - |
Mus musculus | |
kifunensine | complete inhibition at 0.04 mM | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
regulatory T-lymphocyte | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
alpha-1-2-mannosidase | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | alpha-1,2-mannosidase expression increases in CD25+CD4+ regulatory T cells when they encounter alloantigen in vivo | up |
General Information | Comment | Organism |
---|---|---|
malfunction | blocking alpha-1,2-mannosidase in regulatory T cells results in the migration of significantly lower numbers to the peripheral lymph nodes in skin grafted mice following adoptive transfer | Mus musculus |
physiological function | alpha-1,2-mannosidase function is not required for the suppressive capacity of regulatory T cells in vitro, but influences regulatory T cell adherence in vitro andmigration in vivo | Mus musculus |