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Literature summary for 3.2.1.113 extracted from

  • Long, E.T.; Baker, S.; Oliveira, V.; Sawitzki, B.; Wood, K.J.
    Alpha-1,2-mannosidase and hence N-glycosylation are required for regulatory T cell migration and allograft tolerance in mice (2010), PLoS ONE, 5, e8894.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
deoxymannojirimycin
-
Mus musculus
kifunensine complete inhibition at 0.04 mM Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
regulatory T-lymphocyte
-
Mus musculus
-

Synonyms

Synonyms Comment Organism
alpha-1-2-mannosidase
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus alpha-1,2-mannosidase expression increases in CD25+CD4+ regulatory T cells when they encounter alloantigen in vivo up

General Information

General Information Comment Organism
malfunction blocking alpha-1,2-mannosidase in regulatory T cells results in the migration of significantly lower numbers to the peripheral lymph nodes in skin grafted mice following adoptive transfer Mus musculus
physiological function alpha-1,2-mannosidase function is not required for the suppressive capacity of regulatory T cells in vitro, but influences regulatory T cell adherence in vitro andmigration in vivo Mus musculus