Cloned (Comment) | Organism |
---|---|
expression in Cos-1 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
G1363S | misfolded, rest in endoplasmatic reticulum, congenital lactase deficiency, temperature sensitive | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
brush border | - |
Homo sapiens | 5903 | - |
endoplasmic reticulum | misfolded mutation G1363S | Homo sapiens | 5783 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
small intestine | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
20% enzyme activity of mutant G1363S after incubation at 20°C for 22h | Homo sapiens |
additional information | - |
enzymatic activity of mutant G1363S below detection line | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
lactose + H2O | 37°C, 2h | Homo sapiens | D-galactose + D-glucose | - |
? | |
phlorizin | 37°C, 2h | Homo sapiens | phloretin + D-glucose | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | 2* 145000 | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
lactase | - |
Homo sapiens |
lactase phlorizin hydrolase | - |
Homo sapiens |
LPH | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
20 | - |
restoring of enzymatic activity of misfolded mutation G1363S by expression at 20°C | Homo sapiens |