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Literature summary for 3.2.1.102 extracted from

  • Misawa, M.; Watanabe, S.; Ihara, S.; Muramatsu, T.; Matsuzaki, T.
    Accelerated proliferation and abnormal differentiation of epidermal keratinocytes in endo-beta-galactosidase C transgenic mice (2008), Glycobiology, 18, 20-27.
    View publication on PubMed

Application

Application Comment Organism
medicine the absence of the alphaGal epitope or the exposed N-acetylglucosamine terminal in transgenic mice expressing the enzyme can play a critical role in the proliferation of basal keratinocytes and differentiation of them into the spinous cells Clostridium perfringens

Cloned(Commentary)

Cloned (Comment) Organism
expression in Mus musculus Clostridium perfringens

Protein Variants

Protein Variants Comment Organism
additional information mice expressing the enzyme systemically have rough and flaky skin which becomes detectable around 5 days after birth and becomes obscure by 2 weeks after birth. In transgenic mice, proliferating keratinocytes increase approximately 3fold in epidermis compared to wild-type. In transgenic epidermis, the expression domain of cytokeratin 14 increases from 1-2 layers to 4-5 layers and co-expresses with cytokeratin 6 and 10 in the upper layers. Transgenic mice also show delayed development of the barrier function around 8 days postnatal, and acquire the function by 12 days postnatal Clostridium perfringens

Organism

Organism UniProt Comment Textmining
Clostridium perfringens
-
expression in Mus musculus
-

Source Tissue

Source Tissue Comment Organism Textmining