Crystallization (Comment) | Organism |
---|---|
the non-hydrolyzable S-linked azasugars, 1,6-alpa-mannosylthio- and 1,6-alpha-mannobiosylthioisofagomine bind with high affinity to the enzyme. X-ray crystallography shows an atypical interaction of the isofagomine nitrogen with the catalytic acid/base. Molecular dynamics simulations reveal that the atypical binding results from sulfur perturbing the most stable form away from the nucleophile interaction preferred for the O-linked congener | Niallia circulans |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
[(3R,4R, 5R)-4,5-dihydroxypiperidin-3-yl]methyl 1-thio-alpha-D-mannopyranoside | - |
Niallia circulans | |
[(3S,4R,5R)-4,5-dihydroxypiperidin-3-yl]methyl 6-S-alpha-D-mannopyranosyl-1,6-dithio-alpha-D-mannopyranoside | - |
Niallia circulans |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Niallia circulans | Q9Z4P9 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Niallia circulans |
Synonyms | Comment | Organism |
---|---|---|
BcGH76 | - |
Niallia circulans |
endo-1,6-alpha-mannanase | - |
Niallia circulans |