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Literature summary for 3.13.1.3 extracted from
- Desulfination by 2-hydroxybiphenyl-2-sulfinate desulfinase proceeds via electrophilic aromatic substitution by the cysteine-27 proton (2017), Chem. Sci., 8, 5078-5086 .
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2'-hydroxybiphenyl-2-sulfinate + H2O | Rhodococcus erythropolis | the enzyme is involved in biodesulfurization, an option for enzymatically removing sulfur from the recalcitrant thiophenic derivatives that comprise the majority of organosulfur compounds remaining in hydrotreated petroleum products | 2-hydroxybiphenyl + sulfite | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rhodococcus erythropolis | Q6WE14 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2'-hydroxybiphenyl-2-sulfinate + H2O | the enzyme is involved in biodesulfurization, an option for enzymatically removing sulfur from the recalcitrant thiophenic derivatives that comprise the majority of organosulfur compounds remaining in hydrotreated petroleum products | Rhodococcus erythropolis | 2-hydroxybiphenyl + sulfite | - |
? | |
| 2'-hydroxybiphenyl-2-sulfinate + H2O | electrophilic aromatic substitution mechanism. The catalytic cysteine in the enzyme DszB (C27) acts as a proton donor. The nascent ionized C27 at the transition state is stabilized by H60, whose charge is modulated by hydrogen bond interaction with S25 | Rhodococcus erythropolis | 2-hydroxybiphenyl + sulfite | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DszB | - |
Rhodococcus erythropolis |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the enzyme is involved in biodesulfurization, an option for enzymatically removing sulfur from the recalcitrant thiophenic derivatives that comprise the majority of organosulfur compounds remaining in hydrotreated petroleum products | Rhodococcus erythropolis |
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