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Literature summary for 3.11.1.1 extracted from

  • Olsen, D.B.; Hepburn, T.W.; Moos, M.; Mariano, P.S.; Dunaway-Mariano, D.
    Investigation of the Bacillus cereus phosphonoacetaldehyde hydrolase. Evidence for a Schiff base mechanism and sequence analysis of an active-site peptide containing the catalytic lysine residue (1988), Biochemistry, 27, 2229-2234.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
acetonylphosphonate
-
Bacillus cereus
NaBH4 in presence of phosphonoacetaldehyde or acetaldehyde; no effect in absence of substrate or product Bacillus cereus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.04
-
phosphonoacetaldehyde
-
Bacillus cereus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Bacillus cereus
Mg2+ stabilizes the active homodimer form of the enzyme Bacillus cereus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphonoacetylaldehyde + H2O Bacillus cereus second step in the pathway by which Bacillus cereus metabolizes 2-aminoethylphosphonic acid acetaldehyde + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Bacillus cereus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Bacillus cereus

Reaction

Reaction Comment Organism Reaction ID
phosphonoacetaldehyde + H2O = acetaldehyde + phosphate Schiff base mechanism Bacillus cereus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphonoacetylaldehyde + H2O
-
Bacillus cereus acetaldehyde + phosphate
-
?
phosphonoacetylaldehyde + H2O second step in the pathway by which Bacillus cereus metabolizes 2-aminoethylphosphonic acid Bacillus cereus acetaldehyde + phosphate
-
?