Literature summary for 3.1.8.1 extracted from

Jackson, C.J.; Carville, A.; Ward, J.; Mansfield, K.; Ollis, D.L.; Khurana, T.; Bird, S.B.
Use of OpdA, an organophosphorus (OP) hydrolase, prevents lethality in an African green monkey model of acute OP poisoning (2014), Toxicology, 317, 1-5.

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Application

Application	Comment	Organism
medicine	use of organophosphorus hydrolase OpdA prevents lethality in an African green monkey model of acute organophosphrus poisoning. Treated monkeys received 1.2 mg/kg OpdA iv immediately after poisoning with dichlorvos. In Opda-treated animals, heart andrespiratory rates are unchanged from baseline over a 240-minute observation period. AChE activityslowly declines, but remains above 25% of baseline for the entire duration. Dichlorvos concentrationsreach a mean peak of 0.19 microg/ml at 40 min after poisoning and decrease to a mean of 0.05 microg/ml at 240 min	Agrobacterium tumefaciens

Organism

Organism	UniProt	Comment	Textmining
Agrobacterium tumefaciens	Q93LD7	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
dichlorvos + H2O	-	Agrobacterium tumefaciens	2,2-dichloroethenol + dimethyl hydrogen phosphate	-	?

Synonyms

Synonyms	Comment	Organism
OpdA	-	Agrobacterium tumefaciens
phosphotriesterase	-	Agrobacterium tumefaciens

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Release 2023.1 (January 2023)