Protein Variants | Comment | Organism |
---|---|---|
PON1 | the mutant is less able to detoxify diazoxon | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
serum | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
chlorpyrifos oxon + H2O | - |
Mus musculus | 3,5,6-trichloro-pyridin-2-ol + diethyl phosphate | - |
? | |
diazoxon + H2O | - |
Mus musculus | 2-isopropyl-6-methyl-pyrimidin-4-ol + diethyl phosphate | - |
? | |
paraoxon + H2O | - |
Mus musculus | 4-nitrophenol + diethyl phosphate | - |
? |
General Information | Comment | Organism |
---|---|---|
malfunction | paraoxonase 1 knockout mice are dramatically more sensitive than wild type mice to the toxicity of chlorpyrifos oxon and diazoxon and to a lesser extent the parent phosphorothioates, chlorpyrifos and diazinon | Mus musculus |
physiological function | paraoxonase 1 modulates the toxicity of organophosphorous mixtures (paraoxon, chlorpytifoy oxon, diazoxon) by altering the activity of another detoxication enzyme, carboxylesterase | Mus musculus |