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Literature summary for 3.1.8.1 extracted from

  • Cole, T.B.; Jansen, K.; Park, S.; Li, W.F.; Furlong, C.E.; Costa, L.G.
    The toxicity of mixtures of specific organophosphate compounds is modulated by paraoxonase 1 status (2010), Adv. Exp. Med. Biol., 660, 47-60.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.8.1

Protein Variants

Protein Variants Comment Organism
PON1 the mutant is less able to detoxify diazoxon Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
chlorpyrifos oxon + H2O
-
 Mus musculus 3,5,6-trichloro-pyridin-2-ol + diethyl phosphate
-
 ?
diazoxon + H2O
-
 Mus musculus 2-isopropyl-6-methyl-pyrimidin-4-ol + diethyl phosphate
-
 ?
paraoxon + H2O
-
 Mus musculus 4-nitrophenol + diethyl phosphate
-
 ?

General Information

General Information Comment Organism
malfunction paraoxonase 1 knockout mice are dramatically more sensitive than wild type mice to the toxicity of chlorpyrifos oxon and diazoxon and to a lesser extent the parent phosphorothioates, chlorpyrifos and diazinon Mus musculus
physiological function paraoxonase 1 modulates the toxicity of organophosphorous mixtures (paraoxon, chlorpytifoy oxon, diazoxon) by altering the activity of another detoxication enzyme, carboxylesterase Mus musculus