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Literature summary for 3.1.8.1 extracted from

  • Nguyen, S.D.; Hung, N.D.; Cheon-Ho, P.; Ree, K.M.; Dai-Eun, S.
    Oxidative inactivation of lactonase activity of purified human paraoxonase 1 (PON1) (2009), Biochim. Biophys. Acta, 1790, 155-160.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
ascorbate 0.5 mM inhibits by ca. 22%. Ascorbate/Cu2+ (0.5 mM/0.001 mM) system shows ca. 63% inactivation Homo sapiens
Cu2+ Cu2+ alone has no effect. Ascorbate/Cu2+ (0.5 mM/0.001 mM) system shows ca. 63% inactivation Homo sapiens
Fe2+ ascorbate/Fe2+ (0.5 mM/0.002 mM) system shows ca. 27% inactivation after 30 min Homo sapiens
additional information 1 mM 3-morpholinosydnoimine, 0.002 mM Fe2+ or 0.01 mM Mn2+, Co2+, Zn2+, or 0.001 mM Cu2+ cause no significant loss of activity Homo sapiens
sodium hypochlorite at 1 mM and in the presence of PBS buffer causes approximately 49% decrease in activity Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required for the catalysis Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
45000
-
x * 45000, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
by different types of chromatographies Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.391
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
paraoxon + H2O
-
Homo sapiens 4-nitrophenol + diethyl phosphate
-
?

Subunits

Subunits Comment Organism
? x * 45000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
paraoxonase 1
-
Homo sapiens
PON1
-
Homo sapiens