Literature summary for 3.1.8.1 extracted from

van den Berg, S.W.; Jansen, E.H.; Kruijshoop, M.; Beekhof, P.K.; Blaak, E.; van der Kallen, C.J.; van Greevenbroek, M.M.; Feskens, E.J.
Paraoxonase 1 phenotype distribution and activity differs in subjects with newly diagnosed Type 2 diabetes (the CODAM Study) (2008), Diabet. Med., 25, 186-193.

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Application

Application	Comment	Organism
medicine	the RR-phenotype of Q192R with low PON1 activity towards paraoxon and diazoxon is significantly more frequent in newly diagnosed diabetes type 2 subjects compared with normal glucose tolerance subjects	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
Q192R	the homozygote phenotype has significant lower PON1 activity towards paraoxon and diazoxon than the wild type enzyme	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P27169	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
serum	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
diazoxon + H2O	the homozygote wild type enzyme (QQ phenotype of Q192R) hydrolyzes diaxozon more rapidly than paraoxon	Homo sapiens	2-isopropyl-6-methyl-pyrimidin-4-ol + diethyl phosphate	-	?
paraoxon + H2O	-	Homo sapiens	diethylphosphate + 4-nitrophenol	-	?

Synonyms

Synonyms	Comment	Organism
paraoxonase 1	-	Homo sapiens
PON1	-	Homo sapiens

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Release 2023.1 (January 2023)