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Literature summary for 3.1.8.1 extracted from
- High-density lipoprotein cholesterol and paraoxonase 1 (PON1) genetics and serum PON1 activity in prepubertal children in Spain (2008), Clin. Chem. Lab. Med., 46, 809-813.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| L55M | the polymorphism accounts for 73% of PON1 activity | Homo sapiens |
| Q192R | the polymorphism accounts for 69% of PON1 activity, the 192RR genotype carriers have the highest PON1 activity, whereas the the 192QQ genotype carriers have the lowest activity, with the heterozygote 192Q/R having intermediate activity | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P27169 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| serum | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| chlorpyrifos-oxon + H2O | - |
Homo sapiens | 3,5,6-trichloro-2-pyridinol + diethyl phosphate | - |
? |  |
| diazoxon + H2O | - |
Homo sapiens | 2-isopropyl-6-methyl-pyrimidin-4-ol + diethyl phosphate | - |
? | |
| paraoxon + H2O | - |
Homo sapiens | diethylphosphate + 4-nitrophenol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| paraoxonase 1 | - |
Homo sapiens |
| PON1 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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