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Literature summary for 3.1.8.1 extracted from
- Intravenous anesthetics inhibit human paraoxonase-1 (PON1) activity in vitro and in vivo (2008), Clin. Biochem., 41, 1384-1390.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| etomidate | non-competitive inhibitor, PON1 is significantly inhibited by 0.3 mg/kg etomidate for up to 5 min following intravenous administration | Homo sapiens |  |
| Ketamine | uncompetitive inhibitor, PON1 is significantly inhibited by 1 mg/kg ketamine for up to 5 min following intravenous administration | Homo sapiens | |
| propofol | competitive inhibitor, PON1 is significantly inhibited by 2 mg/kg propofol for up to 5 min following intravenous administration | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 43000 | - |
SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P27169 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| ammonium sulfate precipitation, DEAE-Sephadex gel filtration and Sephadex G-200 gel filtration | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| serum | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| paraoxon + H2O | - |
Homo sapiens | diethylphosphate + 4-nitrophenol | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 43000, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| paraoxonase-1 | - |
Homo sapiens |
| PON1 | - |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.059 | - |
etomidate | in 50 mM glycine/NaOH (pH 10.5) containing 1 mM CaCl2, at 25°C | Homo sapiens | |
| 0.322 | - |
propofol | in 50 mM glycine/NaOH (pH 10.5) containing 1 mM CaCl2, at 25°C | Homo sapiens | |
| 6.48 | - |
Ketamine | in 50 mM glycine/NaOH (pH 10.5) containing 1 mM CaCl2, at 25°C | Homo sapiens | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.021 | - |
in 50 mM glycine/NaOH (pH 10.5) containing 1 mM CaCl2, at 25°C | Homo sapiens | etomidate | |
| 0.328 | - |
in 50 mM glycine/NaOH (pH 10.5) containing 1 mM CaCl2, at 25°C | Homo sapiens | propofol | |
| 3.8 | - |
in 50 mM glycine/NaOH (pH 10.5) containing 1 mM CaCl2, at 25°C | Homo sapiens | Ketamine | |
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