Literature summary for 3.1.8.1 extracted from

Rochu, D.; Chabriere, E.; Renault, F.; Elias, M.; Clery-Barraud, C.; Masson, P.
Stabilization of the active form(s) of human paraoxonase by human phosphate-binding protein (2007), Biochem. Soc. Trans., 35, 1616-1620.

Search for more literature for 3.1.8.1

Application

Application	Comment	Organism
additional information	design of stable mutants on PON1-scavengers to be used as safe and effective countermeasures to challenge organophosphates	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expression of wild-type PON1 and PON1-human phosphate-binding protein hybrid in Escherichia coli	Homo sapiens

General Stability

General Stability	Organism
human phosphate-binding protein stabilizes the enzyme and its conformations	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
lipid particle	the enzyme is associated to HDL and human phosphate-binding protein	Homo sapiens	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	PON1 has a protective role e.g. against organophosphorous poisoning, but also against vascular diseases, PON1 has an anti-atherogenic activity	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
serum	-	Homo sapiens	-

Storage Stability

Storage Stability	Organism
human phosphate-binding protein increases the storage stability of PON1	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	PON1 has a protective role e.g. against organophosphorous poisoning, but also against vascular diseases, PON1 has an anti-atherogenic activity	Homo sapiens	?	-	?
additional information	PON1 is associated to HDL and human phosphate-binding protein	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
paraoxonase	-	Homo sapiens
paraoxonase-1	-	Homo sapiens
PON1	-	Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C]	Temperature Stability Maximum [°C]	Comment	Organism
additional information	-	PON1 is highly thermostable, especially when associated to the human phosphate-binding protein	Homo sapiens

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Release 2023.1 (January 2023)