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Literature summary for 3.1.8.1 extracted from
- Clinical study on the effect of simvastatin on paraoxonase activity (2007), Arzneimittelforschung, 57, 647-653.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| simvastatin | used for treatment of hyperlipoproteinemia type IIa and IIb, simvastatin leads to lipid lowering of total and LDL cholesterol and an increase in PON1 activity in patients with both types of hyperlipoproteinemia, mechanism involving apolipoprotein A-I, overview | Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| lipid particle | the enzyme is predominantly associated to high-density lipoprotein HDL | Homo sapiens | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | required | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | the enzyme depends on high-density lipoprotein HDL as carrier and site of action, PON1 acts as an antioxidant preventing low-density lipoprotein peroxidation, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
hyperlipoproteinemia type IIa and IIb patients | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| serum | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme depends on high-density lipoprotein HDL as carrier and site of action, PON1 acts as an antioxidant preventing low-density lipoprotein peroxidation, overview | Homo sapiens | ? | - |
? | |
| paraoxon + H2O | - |
Homo sapiens | diethylphosphate + 4-nitrophenol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| paraoxonase | - |
Homo sapiens |
| PON1 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 10.5 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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