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Literature summary for 3.1.8.1 extracted from
- Analogues with fluorescent leaving groups for screening and selection of enzymes that efficiently hydrolyze organophosphorus nerve agents (2006), J. Med. Chem., 49, 246-255.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetics | Homo sapiens | |
| additional information | - |
additional information | kinetics | Brevundimonas diminuta |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | serum | Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | the enzyme efficiently hydrolyzes organophosphorus nerve agents | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Brevundimonas diminuta | - |
- |
- |
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| serum | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
assay method evaluation of analogues with fluorescent leaving groups for screening and selection of the enzyme that efficiently hydrolyzes organophosphorus nerve agents, overview | Homo sapiens |
| additional information | - |
assay method evaluation of analogues with fluorescent leaving groups for screening and selection of the enzyme that efficiently hydrolyzes organophosphorus nerve agents, overview | Brevundimonas diminuta |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cyclosarin + H2O | - |
Homo sapiens | ? | - |
? | |
| cyclosarin + H2O | - |
Brevundimonas diminuta | methyl-phosphonic acid monofluoride + cyclohexanol | - |
? | |
| diisopropyl fluorophosphate + H2O | - |
Brevundimonas diminuta | ? | - |
? | |
| dimefox + H2O | - |
Brevundimonas diminuta | ? | - |
? | |
| methyl paraoxon + H2O | - |
Homo sapiens | 4-nitrophenol + dimethyl phosphate | - |
? | |
| methyl paraoxon + H2O | - |
Brevundimonas diminuta | 4-nitrophenol + dimethyl phosphate | - |
? | |
| methyl parathion + H2O | - |
Brevundimonas diminuta | 4-nitrophenol + dimethyl thiophosphate | - |
? | |
| additional information | the enzyme efficiently hydrolyzes organophosphorus nerve agents | Homo sapiens | ? | - |
? | |
| additional information | no activity with dimefox, parathion, methyl parathion, and diisopropyl fluorophosphate, assay method evaluation of analogues with fluorescent leaving groups for screening and selection of the enzyme that efficiently hydrolyzes organophosphorus nerve agents, overview | Homo sapiens | ? | - |
? | |
| paraoxon + H2O | - |
Homo sapiens | 4-nitrophenol + diethyl phosphate | - |
? | |
| paraoxon + H2O | - |
Brevundimonas diminuta | 4-nitrophenol + diethyl phosphate | - |
? | |
| parathion + H2O | - |
Brevundimonas diminuta | 4-nitrophenol + diethyl thiophosphate | - |
? | |
| russian VX + H2O | - |
Homo sapiens | methyl-phosphonothioic acid S-(2-diethylamino-ethyl) ester + 2-methylpropanol | - |
? | |
| russian VX + H2O | - |
Brevundimonas diminuta | methyl-phosphonothioic acid S-(2-diethylamino-ethyl) ester + 2-methylpropanol | - |
? | |
| sarin + H2O | - |
Homo sapiens | methyl-phosphonic acid monofluoride + isopropyl alcohol | - |
? | |
| sarin + H2O | - |
Brevundimonas diminuta | methyl-phosphonic acid monofluoride + isopropyl alcohol | - |
? | |
| soman + H2O | - |
Homo sapiens | methyl-phosphonic acid monofluoride + 1,2,2-trimethylpropanol | - |
? | |
| soman + H2O | - |
Brevundimonas diminuta | methyl-phosphonic acid monofluoride + 1,2,2-trimethylpropanol | - |
? | |
| tabun + H2O | - |
Homo sapiens | cyanophosphonic acid dimethylamide + ethanol | - |
? | |
| tabun + H2O | - |
Brevundimonas diminuta | cyanophosphonic acid dimethylamide + ethanol | - |
? | |
| VX + H2O | - |
Homo sapiens | S-[2-(diisopropylamino)ethyl]-methylphosphonothioic acid + ethanol | - |
? | |
| VX + H2O | - |
Brevundimonas diminuta | S-[2-(diisopropylamino)ethyl]-methylphosphonothioic acid + ethanol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| paraoxonase 1 | - |
Homo sapiens |
| phosphotriesterase | - |
Brevundimonas diminuta |
| PON1 | - |
Homo sapiens |
| PTE | - |
Brevundimonas diminuta |
| serum paraoxonase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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