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Literature summary for 3.1.8.1 extracted from
- The importance of high-density lipoproteins for paraoxonase-1 secretion, stability, and activity (2004), Free Radic. Biol. Med., 37, 1986-1994.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene PON1, DNA and amino acid sequence determination and analysis, gene structure, expression in CHO cells and in human hepatocyte Huh-7 cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | naturally occurring polymorphism Q192R | Homo sapiens |
General Stability
| General Stability | Organism |
|---|---|
| the HDL composition has an influence on the enzyme stability, overview | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | the enzyme is secreted to serum mediated by the associated high-density lipoproteins HDL | Mus musculus | - |
- |
| extracellular | the enzyme is secreted to serum mediated by the associated high-density lipoproteins HDL, the interaction may promote enzyme secretion, determination of influence of HDL and its composition on mediation of enzyme secretion, overview | Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | the enzyme associated to high-density lipoproteins HDL exhibits antioxidant function of particular physiological relevance, mechanism, compositional fluctuations of HDL effects the influence of the enzyme on cardiovascular risks, overview | ? | - |
? |  |
| additional information | Homo sapiens | the enzyme associated to high-density lipoproteins HDL exhibits antioxidant function of particular physiological relevance, mechanism, compositional fluctuations of HDL effects the influence of the enzyme on cardiovascular risks, overview, PON1 content is reduced in human ApoAI deficiency disease | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
isozymes PON1-PON3 | - |
| Mus musculus | - |
isozymes PON1 and PON2 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| PON1-HDL complex, overview | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | main localization of enzyme production | Mus musculus | - |
| liver | main localization of enzyme production | Homo sapiens | - |
| serum | - |
Mus musculus | - |
| serum | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme associated to high-density lipoproteins HDL exhibits antioxidant function of particular physiological relevance, mechanism, compositional fluctuations of HDL effects the influence of the enzyme on cardiovascular risks, overview | Mus musculus | ? | - |
? | |
| additional information | the enzyme associated to high-density lipoproteins HDL exhibits antioxidant function of particular physiological relevance, mechanism, compositional fluctuations of HDL effects the influence of the enzyme on cardiovascular risks, overview, PON1 content is reduced in human ApoAI deficiency disease | Homo sapiens | ? | - |
? | |
| additional information | enzyme-HDL complex: interaction and structure analysis | Mus musculus | ? | - |
? | |
| additional information | enzyme-HDL complex: interaction and structure analysis | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | high-density lipoproteins HDL form an amphipathic environment for the associated enzyme whose hydrophobic, N-terminal region is shielded by that way required for the substrate binding of PON1 | Mus musculus |
| More | isozyme PON1 contains an N-terminal signal peptide sequence for secretion, high-density lipoproteins HDL form an amphipathic environment for the associated enzyme whose hydrophobic, N-terminal region is shielded by that way required for the substrate binding of PON1, interaction and structure analysis | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HDL-PON1 | - |
Mus musculus |
| HDL-PON1 | - |
Homo sapiens |
| paraoxonase-1 | - |
Mus musculus |
| paraoxonase-1 | - |
Homo sapiens |
| PON1 | - |
Mus musculus |
| PON1 | - |
Homo sapiens |
| PON2 | - |
Mus musculus |
| PON2 | - |
Homo sapiens |
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