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Literature summary for 3.1.8.1 extracted from
- Measurement of paraoxonase (PON1) status as a potential biomarker of susceptibility to organophosphate toxicity (2005), Clin. Chim. Acta, 352, 37-47.
Application
| Application | Comment | Organism |
|---|---|---|
| analysis | PON1 status can be used as a potential biomarker for insecticides metabolites in urine, e.g. dimethyl phosphate and diethyl phosphate, and of susceptibility to organophosphate toxicity, overview | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | analysis of PON1 polymorphisms, e.g. at residue Q192R, overview | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | secreted from the liver into the blood serum | Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | the enzyme is important in detoxification of organophosphorus compounds, structure and applications of organophosphorus compounds, clinical evidence of PON1, overview | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
| serum | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| diazoxon + H2O | - |
Homo sapiens | 6-methyl-2-(1-methylethyl)pyrimidin-4-ol + diethyl phosphate | - |
ir | |
| additional information | the enzyme is important in detoxification of organophosphorus compounds, structure and applications of organophosphorus compounds, clinical evidence of PON1, overview | Homo sapiens | ? | - |
? | |
| paraoxon + H2O | - |
Homo sapiens | 4-nitrophenol + diethyl phosphate | - |
ir | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| paraoxonase | - |
Homo sapiens |
| PON1 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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