Literature summary for 3.1.8.1 extracted from

Banzon, J.A.; Kuo, J.M.; Miles, B.W.; Fischer, D.R.; Stang, P.J.; Raushel, F.M.
Mechanism-based inactivation of phosphotriesterase by reaction of a critical histidine with a ketene intermediate (1995), Biochemistry, 34, 743-749.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1-hexynyl diethyl phosphate	rapid inactivation, reactiviation by increasing pH	Brevundimonas diminuta
1-hexynyl dimethyl phosphate	rapid inactivation, reactiviation by increasing pH	Brevundimonas diminuta
1-hexynyl diphenyl phosphate	rapid inactivation, reactiviation by increasing pH	Brevundimonas diminuta
1-propynyl diethyl phosphate	rapid inactivation, reactiviation by increasing pH	Brevundimonas diminuta
ethynyl diethyl phosphate	rapid inactivation, reactiviation by increasing pH	Brevundimonas diminuta

Organism

Organism	UniProt	Comment	Textmining
Brevundimonas diminuta	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol	mechanism	Brevundimonas diminuta	a

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Release 2023.1 (January 2023)