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Literature summary for 3.1.8.1 extracted from
- Identification of two rat liver proteins with paraoxonase activity: biochemical evidence for the identity of paraoxonase and arylesterase (1999), Chem. Biol. Interact., 119-120, 263-275.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Co3+ | - |
Rattus norvegicus |  |
| Cu2+ | - |
Rattus norvegicus | |
| EDTA | - |
Rattus norvegicus | |
| Hg2+ | - |
Rattus norvegicus | |
| Mg2+ | - |
Rattus norvegicus | |
| Mn2+ | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.63 | - |
paraoxon | pH 8.5, 37°C, enzyme form M2 | Rattus norvegicus | |
| 2.69 | - |
paraoxon | pH 8.5, 37°C, enzyme form M1 | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | optimal concentration is 2 mM | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 45000 | - |
x * 45000, SDS-PAGE | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | two proteins capable of hydrolyzing paraoxon are present in rat liver microsomes, enzyme form M1 and M2 | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| paraoxon + H2O | - |
Rattus norvegicus | diethylphosphate + 4-nitrophenol | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 45000, SDS-PAGE | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| paraoxonase | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
assay at | Rattus norvegicus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.002 | - |
pH 8.5, 37°C, enzyme form M2 | Rattus norvegicus | Hg2+ | |
| 0.014 | - |
pH 8.5, 37°C, enzyme form M1 | Rattus norvegicus | Hg2+ | |
| 0.08 | - |
pH 8.5, 37°C, enzyme form M2 | Rattus norvegicus | Co3+ | |
| 0.09 | - |
pH 8.5, 37°C, enzyme form M2 | Rattus norvegicus | Mn2+ | |
| 0.2 | - |
pH 8.5, 37°C, enzyme form M1 | Rattus norvegicus | Mn2+ | |
| 0.28 | - |
pH 8.5, 37°C, enzyme form M1 | Rattus norvegicus | Co3+ | |
| 0.6 | - |
pH 8.5, 37°C, enzyme form M2 | Rattus norvegicus | Cu2+ | |
| 1.5 | - |
pH 8.5, 37°C, enzyme form M1 | Rattus norvegicus | Cu2+ | |
| 2.3 | - |
pH 8.5, 37°C, enzyme form M2 | Rattus norvegicus | Mg2+ | |
| 5 | - |
pH 8.5, 37°C, enzyme form M1 | Rattus norvegicus | Mg2+ | |
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