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Literature summary for 3.1.8.1 extracted from

  • Aviram, M.; Rosenblatt, M.; Bisgaier, C.L.; Newton, R.S.; Primo-Parmo, S.L.; La Du, B.N.
    Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase (1998), J. Clin. Invest., 101, 1581-1590.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.8.1

Inhibitors

Inhibitors Comment Organism Structure
1-(4-chlorophenyl)-4-(dimethylamino)butan-1-ol
-
 Homo sapiens
1-biphenyl-4-yl-3-(dimethylamino)propan-1-one
-
 Homo sapiens
2-(4-[[2-methoxy-5-(methylsulfonyl)phenyl]carbonyl]piperazin-1-yl)ethanol
-
 Homo sapiens
7-(4-methylbenzyl)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens high-density lipoprotein-associated paraoxonase possesses peroxidase-like activity that can contribute to the protective effect of paraoxonase against lipoprotein oxidation. The presence of paraoxonase in high-density lipoprotein may thus be a major contributor to the antiatherogenicity of this lipoprotein ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood serum
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information high-density lipoprotein-associated paraoxonase possesses peroxidase-like activity that can contribute to the protective effect of paraoxonase against lipoprotein oxidation. The presence of paraoxonase in high-density lipoprotein may thus be a major contributor to the antiatherogenicity of this lipoprotein Homo sapiens ?
-
 ?
paraoxon + H2O
-
 Homo sapiens 4-nitrophenol + diethylphosphate
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
10.5
-
 assay at Homo sapiens