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Literature summary for 3.1.8.1 extracted from

  • Gonzalo, M.C.; Gil, F.; Hernandez, A.F.; Rodrigo, L.; Villanueva, E.; Pla, A.
    Human liver paraoxonase (PON1): subcellular distribution and characterization (1998), J. Biochem. Mol. Toxicol., 12, 61-69.
    View publication on PubMed
Search for more literature for 3.1.8.1

Inhibitors

Inhibitors Comment Organism Structure
EDTA at 1 mM, 100% of inhibition Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.29
-
 paraoxon
-
 Homo sapiens
0.29
-
 paraoxon 37°C, pH 10.0 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ requirement Homo sapiens
Ca2+ required, cannot be replaced by Mg2+, Ba2+, Cu2+, Ca2+, Mn2+, Co2+, Zn2+ or Hg2+ Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens
-
 isoform PON1
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
paraoxon + H2O
-
 Homo sapiens diethylphosphate + 4-nitrophenol
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
45
-
 60 min, stable Homo sapiens
52
-
 inactivation Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
10 10.5
-
 Homo sapiens