Inhibitors | Comment | Organism | Structure |
---|---|---|---|
farnesyl monophosphate | - |
Rattus norvegicus | |
geranylgeranyl diphosphate | potent noncompetitive inhibitor | Rattus norvegicus | |
zaragozic acid B | i.e. L694,581, mixed type inhibition at 0.04 mM. No inhibition by zaragozic acid A up to 0.1 mM | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | the KM-value for (2E,6E)-farnesyl diphosphate increases with an increase in pH | Rattus norvegicus | |
0.007 | - |
(2E,6E)-farnesyl diphosphate | pH 5.5, 37°C | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | the activity is metal ion independent | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2E,6E)-farnesyl diphosphate + H2O | Rattus norvegicus | - |
(2E,6E)-farnesol + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0068 | - |
- |
Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2E,6E)-farnesyl diphosphate + H2O | - |
Rattus norvegicus | (2E,6E)-farnesol + diphosphate | - |
? | |
(2E,6E)-farnesyl diphosphate + H2O | - |
Rattus norvegicus | (2E,6E)-farnesol + diphosphate | diphosphate not determined | ? |
Synonyms | Comment | Organism |
---|---|---|
farnesyl pyrophosphatase | - |
Rattus norvegicus |
FPPase | - |
Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.5 | - |
- |
Rattus norvegicus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5 | 6.2 | pH 5.0: about 45% of maximal activity, pH 6.2: about 75% of maximal activity | Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.005 | - |
pH 5.5, 37°C | Rattus norvegicus | geranylgeranyl diphosphate | |
0.02 | - |
- |
Rattus norvegicus | zaragozic acid B | |
0.07 | - |
pH 5.5, 37°C | Rattus norvegicus | farnesyl monophosphate |