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Literature summary for extracted from

  • Sato-Masumoto, N.; Ito, M.
    A domain swapping approach to elucidate differential regiospecific hydroxylation by geraniol and linalool synthases from perilla (2014), Phytochemistry, 102, 46-54.
    View publication on PubMed


Cloned (Comment) Organism
Perilla frutescens var. hirtella

Protein Variants

Protein Variants Comment Organism
additional information construction of domain swapping mutants between geraniol synthase from Perilla citriodora and linalool synthase from Perilla hirtella. Domains IV-1 and -4 are important for geraniol synthesis, and domains III-b, III-d, and IV-4 for linalool synthesis. The conformation of carbocation intermediates and their electron localization seem different between geraniol and linalool synthases. Five amino acids in domain IV-4 are indispensable for the formation of geraniol and linalool. These residues seem to be responsible for the different spatial arrangement of the amino acid at H524 in the case of geraniol synthase, while N526 is the corresponding residue in linalool synthase Perilla frutescens var. hirtella


Organism UniProt Comment Textmining
Perilla frutescens var. hirtella Q4JHG3