Activating Compound | Comment | Organism | Structure |
---|---|---|---|
bis(monoacylglycero) phosphate | at a relative concentration of 30 mol% the lipid stimulates the reaction rate by a factor of 3.4 | Homo sapiens | |
dolichol | at a relative concentration of 30 mol% the lipid stimulates the reaction rate by a factor of 2.7 | Homo sapiens | |
additional information | phosphatidylinositol and phosphatidylserine have no effect on the rate of sulfatide hydrolysis | Homo sapiens | |
phosphatidic acid | at a relative concentration of 30 mol% the lipid stimulates the reaction rate by a factor of 3.1 | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in baby hamster kidney cells and CHO cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | CaCl2 reduces the reaction rate in the low millimolar range | Homo sapiens | |
Mg2+ | MgCl2 reduces the reaction rate in the low millimolar range | Homo sapiens | |
Mn2+ | MnCl2 reduces the reaction rate in the low millimolar range | Homo sapiens | |
Na+ | enzymatic activity is inhibited at NaCl concentrations exceeding 20 mM, at 50 and 200 mM the rate of sulfatide hydrolysis is diminished by about 50 and 75%, respectively | Homo sapiens | |
phosphate | competitive inhibitor | Homo sapiens | |
sulfite | competitive inhibitor | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrocatechol sulfate + H2O | - |
Homo sapiens | 4-nitrocatechol + sulfate | - |
? | |
4-nitrophenyl sulfate + H2O | - |
Homo sapiens | 4-nitrophenol + sulfate | - |
? | |
cerebroside 3-sulfate + H2O | the reaction requires saposin B, a non-enzymatic proteinaceous cofactor which presents sulfatide to the catalytic site of arylsulfatase A, desulfation is negligible when Sap B is substituted by Sap A, C, or D | Homo sapiens | cerebroside + sulfate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
arylsulfatase A | - |
Homo sapiens |
ASA | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
4.3 | - |
narrow pH optimum around pH 4.3 | Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
3.75 | 4.75 | desulfation activity is less than half-maximum at pH values below pH 3.75 and above pH 4.75 | Homo sapiens |