Application | Comment | Organism |
---|---|---|
medicine | therapeutic levels of ARSA overexpression can be safetly achieved. ARSA-transduced cells efficiently repopulate the hematopoietic organs of RAG2-/- gamma-chain-/- mice. ARSA overexpression does not impair clonogenic capacity and multilineage differentiation of human HSPC cells, activation of other sulfatases and is thus unlikely to trigger metabolic imbalances. Moreover, ARSA overexpression does not impair immune functions, behavior and learning abilities | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
HSPC cells transduced with increasing doses of lentiviral vectors expressing ARSA under the control of the human PGK promoter (PGK.ARSA.LV). Transgenic mice generated with PGK.ARSA.LV overexpressing the ARSA enzyme | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-lissamine rhodaminyl-(12-aminododecanoyl)cerebroside 3-sulfate + H2O | - |
Homo sapiens | ? | - |
? | |
p-nitrocatechol sulfate + H2O | - |
Homo sapiens | p-nitrocatechol + sulfate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ARSA | - |
Homo sapiens |
arylsulfatase A | - |
Homo sapiens |