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Literature summary for 3.1.6.8 extracted from
- Comparison of the cerebroside sulphatase and the arylsulphatase activity of human sulphatase A in the absence of activators (1975), Biochim. Biophys. Acta, 377, 126-138.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| ceramide | inhibition or activation depends on substrate | Homo sapiens |  |
| cerebroside | inhibition or activation depends on substrate | Homo sapiens | |
| phosphatidylcholine | inhibition or activation depends on substrate | Homo sapiens | |
| Protein factor | no requirement for activators when acting on cerebroside sulfate | Homo sapiens | |
| psychosine | inhibition or activation is substrate-dependent | Homo sapiens | |
| sphingomyelin | inhibition or activation depends on substrate | Homo sapiens | |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | deficiency in metachromatic leukodystrophy, a sphingolipid storage disorder | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ceramide | inhibition or activation depends on substrate | Homo sapiens | |
| cerebroside | inhibition or activation depends on substrate | Homo sapiens | |
| nitrocatechol sulfate | noncompetitive inhibition | Homo sapiens | |
| phophatidylinositol | inhibition or activation depends on substrate | Homo sapiens | |
| phosphatidylcholine | inhibition or activation depends on substrate | Homo sapiens | |
| psychosine | inhibition or activation is substrate-dependent | Homo sapiens | |
| sphingomyelin | inhibition or activation depends on substrate | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.06 | - |
cerebroside 3-sulfate | in presence of 10 mM sodium formate | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| lysosome | - |
Homo sapiens | 5764 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cerebroside 3-sulfate + H2O | Homo sapiens | - |
cerebroside + sulfate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cerebroside 3-sulfate + H2O | - |
Homo sapiens | cerebroside + sulfate | - |
? | |
| cerebroside 3-sulfate + H2O | activity depends on ionic strength | Homo sapiens | cerebroside + sulfate | - |
? | |
| cerebroside 3-sulfate + H2O | no requirement for activators when acting on cerebroside sulfate | Homo sapiens | cerebroside + sulfate | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 4.5 | - |
50 mM sodium formate buffer | Homo sapiens |
| 5.3 | - |
10 mM sodium formate buffer | Homo sapiens |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 4 | 5.8 | pH 4, pH 5.8: circa 20% of activity maximum, 10 mM sodium formate buffer | Homo sapiens |
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