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Literature summary for 3.1.6.4 extracted from

  • Lim, C.T.; Horwitz, A.L.
    Purification and properties of human N-acetylgalactosamine-6-sulfate sulfatase (1981), Biochim. Biophys. Acta, 657, 344-355.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
6-Sulfated heptasaccharides strong Homo sapiens
6-Sulfated pentasaccharides strong Homo sapiens
chondroitin 4-sulfate slight Homo sapiens
Chondroitin 6-sulfate tetrasaccharide slight Homo sapiens
dermatan sulfate slight Homo sapiens
heparin slight Homo sapiens
hyaluronic acid slight Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.12
-
N-acetylgalactosamine 6-sulfate-beta(1-4)glucuronic acid-beta(1-3)-N-acetylgalactosaminitol 6-sulfate
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
85000
-
x * 85000, SDS-PAGE Homo sapiens
90000
-
gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
Homo sapiens
-
skin fibroblast Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.000653
-
enzyme from fibroblasts Homo sapiens
0.00073
-
enzyme from placenta Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information does not hydrolyze sulfate from N-acetylglucosamine 6-sulfate Homo sapiens ?
-
?
N-acetylgalactosamine 6-sulfate-beta(1-4)glucuronic acid-beta(1-3)-N-acetylgalactosaminitol 6-sulfate + H2O sulfate is hydrolyzed only from the non-reducing terminal Homo sapiens sulfate + ?
-
?

Subunits

Subunits Comment Organism
? x * 85000, SDS-PAGE Homo sapiens