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Literature summary for 3.1.6.2 extracted from

  • Dasko, M.; Przybylowska, M.; Rachon, J.; Maslyk, M.; Kubinski, K.; Misiak, M.; Skladanowski, A.; Demkowicz, S.
    Synthesis and biological evaluation of fluorinated N-benzoyl and N-phenylacetoyl derivatives of 3-(4-aminophenyl)-coumarin-7-O-sulfamate as steroid sulfatase inhibitors (2017), Eur. J. Med. Chem., 128, 79-87 .
    View publication on PubMed
Search for more literature for 3.1.6.2

Crystallization (Commentary)

Crystallization (Comment) Organism
molecular docking of inhibitors 3-[4-(3,4-difluoro-benzoylamino)-phenyl]-coumarin-7-O-sulfamate, 3-[4-[2-(2,5-bis-trifluoromethyl-phenyl)-acetylamino]-phenyl]-coumarin-7-O-sulfamate. Predicted free docking energies are in the range of -7.6 to -9.5 kcal/mol Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3-[4-(3,4-difluoro-benzoylamino)-phenyl]-coumarin-7-O-sulfamate compound exhibits poor cytotoxicity Homo sapiens
3-[4-[2-(2,5-bis-trifluoromethyl-phenyl)-acetylamino]-phenyl]-coumarin-7-O-sulfamate compound shows antiproliferative activity against the MCF-7 and T47D cell lines, GI50 value is 15.9 microM and 8.7 microM, respectively Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P08842
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MCF-7 cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-
SK-BR-3 cell
-
 Homo sapiens
-
T-47D cell
-
 Homo sapiens
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00018
-
 pH 7.4, 37°C Homo sapiens 3-[4-(3,4-difluoro-benzoylamino)-phenyl]-coumarin-7-O-sulfamate
0.0018
-
 pH 7.4, 37°C Homo sapiens 3-[4-[2-(2,5-bis-trifluoromethyl-phenyl)-acetylamino]-phenyl]-coumarin-7-O-sulfamate