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Literature summary for 3.1.6.2 extracted from

  • Ganeshapillai, D.; Woo, L.W.L.; Thomas, M.P.; Purohit, A.; Potter, B.V.L.
    C-3- and C-4-substituted bicyclic coumarin sulfamates as potent steroid sulfatase inhibitors (2018), ACS omega, 3, 10748-10772 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.6.2

Crystallization (Commentary)

Crystallization (Comment) Organism
molecular docking of inhibitors 3-hexyl-4-methylcoumarin-7-O-sulfamate and 3-benzyl-4-methylcoumarin-7-O-sulfamate into the active site of steryl sulfatase Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3-benzyl-4-methylcoumarin-7-O-sulfamate IC50 value 0.68 nM in intact MCF-7 cells Homo sapiens
3-hexyl-4-methylcoumarin-7-O-sulfamate IC50 value 0.68 nM in intact MCF-7 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
 Homo sapiens
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.008
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 3-hexyl-4-methylcoumarin-7-O-sulfamate
0.032
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 3-benzyl-4-methylcoumarin-7-O-sulfamate