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Literature summary for 3.1.6.2 extracted from

  • Suzuki, T.; Miki, Y.; Nakamura, Y.; Ito, K.; Sasano, H.
    Steroid sulfatase and estrogen sulfotransferase in human carcinomas (2011), Mol. Cell. Endocrinol., 340, 148-153.
    View publication on PubMed
Search for more literature for 3.1.6.2

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
estrone sulfate + H2O Homo sapiens estrone is locally produced from circulating inactive estrone sulfate by steroid sulfatase estrone + sulfate
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast carcinoma cell steroid sulfatase enzyme activity is detected in the great majority of breast carcinomas Homo sapiens
-
carcinoma cell
-
 Homo sapiens
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colonic cancer cell
-
 Homo sapiens
-
endometrial cancer cell
-
 Homo sapiens
-
ovary cancer cell
-
 Homo sapiens
-
prostate gland cancer cell
-
 Homo sapiens
-
uterine endometrial carcinoma cell
-
 Homo sapiens
-
uterine endometrium
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
estrone sulfate + H2O
-
 Homo sapiens estrone + sulfate
-
 ?
estrone sulfate + H2O estrone is locally produced from circulating inactive estrone sulfate by steroid sulfatase Homo sapiens estrone + sulfate
-
 ?

Synonyms

Synonyms Comment Organism
steroid sulfatase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens steroid sulfatase expression is upregulated in breast carcinomas up

General Information

General Information Comment Organism
malfunction steroid sulfatase/estrogen sulfotransferase status is associated with intratumoral estrogen level in the colon carcinoma, and steroid sulfatase-negative/estrogen sulfotransferase-positive colon carcinoma patients have longer survival. STS mRNA expression is higher in breast carcinoma tissues than that in normal breast tissues, and it is significantly associated with the breast carcinoma progression and poor clinical outcome of the patients Homo sapiens
physiological function activation of steroid sulfatase pathway due to increment in steroid sulfatase and/or decrement in estrogen sulfotransferase expressions plays important role in their estrogen-dependent growth Homo sapiens