Literature summary for 3.1.6.2 extracted from

Purohit, A.; Chander, S.K.; Woo, L.W.; Parsons, M.F.; Jhalli, R.; Potter, B.V.; Reed, M.J.
Inhibition of steroid sulphatase activity via the percutaneous route: a new option for breast cancer therapy (2008), Anticancer Res., 28, 1517-1523.

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Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	STS inhibitors were developed to treat breast cancer but could also used to treat endometriosis, polycystic ovarian disease, prostate cancer, and some androgen-dependent skin conditions, such as acne and hirsutism	Mus musculus
STX289	N,N-dimethyl 667 COUMATE, analogue of STX64, inhibition 24 h after oral application: 0.1 mg/kg inhibits liver STS by 45%, skin STS by about 39%, 1 and 10 mg/kg inhibit liver STS completely, skin STS almost completely, inhibition 24 h after topical application to neck skin: 0.1 mg/kg inhibits skin and liver STS by <50%, remote skin STS by about 10%, 1and 10 mg/kg inhibit skin STS by 98%, remote skin STS by about 80 and more than 90% respectively, and liver STS by more than 80 and close by 100% respectively	Mus musculus
STX64	synonym BN83495, inhibition 24 h after oral application: 0.1 mg/kg body mass inhibits liver STS by 79%, skin STS by about 59%, 1 and 10 mg/kg inhibitis liver STS activity completely, skin STS almost completely, inhibition 24 h after topical application to neck skin: 0.1 mg/kg inhibits skin STS by 95%, remote skin STS by about 33%, liver STS by 45%, 1 and 10 mg/kg inhibits skin STS by 99%, remote skin STS almost completely, and liver STS by about 90%	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
dehydroepiandrosterone sulfate + H2O	Mus musculus	-	dehydroepiandrosterone + sulfate	subsequent conversion to testosterone or aromatisation to estrone	?
estrone sulfate + H2O	Mus musculus	-	estrone + sulfate	subsequent conversion to estradiol	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	athymic female MF-1 nude mice	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Mus musculus	-
skin	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
dehydroepiandrosterone sulfate + H2O	-	Mus musculus	dehydroepiandrosterone + sulfate	subsequent conversion to testosterone or aromatisation to estrone	?
estrone sulfate + H2O	-	Mus musculus	estrone + sulfate	subsequent conversion to estradiol	?

Synonyms

Synonyms	Comment	Organism
steroid sulfatase	-	Mus musculus
STS	-	Mus musculus

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Release 2023.1 (January 2023)