Activating Compound | Comment | Organism | Structure |
---|---|---|---|
interleukin 6 | plus tumor necrosis factor alpha, increases STS activity in mock transfected MCF-7 cells and further increases STS activity in transfected MCF-7 cells, activation occurs independently of STS promoter and enhancer elements, may activate via a post-translational modification of STS or by increasing substrate availability | Homo sapiens | |
Tumor necrosis factor alpha | plus interleucin 6, increases STS activity in mock transfected MCF-7 cells and further increases STS activity in transfected MCF-7 cells, activation occurs independently of STS promoter and enhancer elements, may activate via a post-translational modification of STS or by increasing substrate availability | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
2.4 kb STS cDNA, expression in MCF-7 and COS-1 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-methoxyestrone-3-O-sulfamate | potent active site-directed inhibitor, no effect on STS mRNA expression in fibroblasts | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the action of STS makes a major contribution to the in situ estrogen production in breast tumors | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
women | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast | fibroblasts from normal and malignant breast tissue, study of the regulation of STS mRNA expression | Homo sapiens | - |
breast cancer cell | expression of STS mRNA and STS activity are increased in malignant breast tissues compared with that in non-malignant tissues | Homo sapiens | - |
fibroblast | from normal and malignant breast tissue, study of the regulation of STS mRNA expression, expression in fibroblasts derived from breast tissue proximal to tumors, breast tumor tissue and reduction mammoplasty tissue, effect of menopausal status | Homo sapiens | - |
MCF-7 cell | breast cancer cells, study of the regulation of STS mRNA expression | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
estrone sulfate + H2O | - |
Homo sapiens | estrone + sulfate | - |
? | |
additional information | the action of STS makes a major contribution to the in situ estrogen production in breast tumors | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
STS | - |
Homo sapiens |