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Literature summary for 3.1.6.2 extracted from
- Subunits of neurosteroid sulfatase from bovine brain (2000), J. Steroid Biochem. Mol. Biol., 73, 135-139.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Triton X-100 | activates | Bos taurus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Bos taurus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 38000 | - |
alpha2,beta2, 2 * 57000 + 2 * 38000, two 57 kDa catalytic and two 38 kDa regulatory subunits, SDS-PAGE | Bos taurus |
| 57000 | - |
alpha2,beta2, 2 * 57000 + 2 * 38000, two 57 kDa catalytic and two 38 kDa regulatory subunits, SDS-PAGE | Bos taurus |
| 180000 | - |
gel filtration, in the presence of Triton X-100 | Bos taurus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Bos taurus | NSS likely plays a key role in the regulation of the GABA-A receptor | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
2-2.5 years old females | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| 99.3fold | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.000002961 | - |
- |
Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dehydroepiandrosterone sulfate + H2O | - |
Bos taurus | dehydroepiandrosterone + sulfate | - |
? | |
| additional information | NSS likely plays a key role in the regulation of the GABA-A receptor | Bos taurus | ? | - |
? | |
| pregnenolone sulfate + H2O | - |
Bos taurus | pregnenolone + sulfate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heterotetramer | alpha2,beta2, 2 * 57000 + 2 * 38000, two 57 kDa catalytic and two 38 kDa regulatory subunits, SDS-PAGE | Bos taurus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| neurosteroid sulfatase | - |
Bos taurus |
| NSS | - |
Bos taurus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Bos taurus |
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Release 2023.1 (January 2023)
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