Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.6.2 extracted from

  • Hoffmann, R.; Rot, A.; Niiyama, S.; Billich, A.
    Steroid sulfatase in the human hair follicle concentrates in the dermal papilla (2001), J. Invest. Dermatol., 117, 1342-1348.
    View publication on PubMed
Search for more literature for 3.1.6.2

Application

Application Comment Organism
pharmacology steroid sulfatase inhibitors could be novel drugs to treat androgen-dependent disorders of the hair follicle such as androgenetic alopecia or hirsutism Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
estrone-3-O-sulfamate specific inhibitor, concentration-dependent, complete inhibition at 0.1 mM, 100 nM and 10 nM, 89% inhibition at 1 nM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0017
-
 dehydroepiandrosterone sulfate
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dehydroepiandrosterone sulfate + H2O Homo sapiens androgen metabolism, dehydroepiandrosterone sulfate may play a part in the pathogenesis of androgenic alopecia dehydroepiandrosterone + sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hair follicle scalp biopsies, beard and occipital hair follicles ex vivo, predominantly expressed in the dermal papilla Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 higher specific activity in the dermal papilla by a factor of 6-8 than in the connective tissue sheaths or root sheaths Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dehydroepiandrosterone sulfate + H2O
-
 Homo sapiens dehydroepiandrosterone + sulfate
-
 ?
dehydroepiandrosterone sulfate + H2O androgen metabolism, dehydroepiandrosterone sulfate may play a part in the pathogenesis of androgenic alopecia Homo sapiens dehydroepiandrosterone + sulfate
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens