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Literature summary for 3.1.6.2 extracted from

  • Bonser, J.; Walker, J.; Purohit, A.; Reed, M.J.; Potter, B.V.L.; Willis, D.S.; Franks, S.; Mason, H.D.
    Human granulosa cells are a site of sulphatase activity and are able to utilize dehydroepiandrosterone sulphate as a precursor for oestradiol production (2000), J. Endocrinol., 167, 465-471.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Insulin human recombinant insulin, 30% activation at 10 ng/ml Homo sapiens

Application

Application Comment Organism
medicine blocking of dehydroepiandrosterone sulfate sulfatase activity could be prove to be clinically important in oestrogen-dependent tumors in pre-menopausal women Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
estrone-3-O-sulfamate potent inhibitor, dose-dependent, maximum inhibition between 100 and 1000 nM Homo sapiens
human pituitary luteinizing hormone human pituitary LH, reduces activity to 85% of baseline at 5 ng/ml, dose-dependent Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dehydroepiandrosterone sulfate + H2O Homo sapiens oestrogen biosynthesis dehydroepiandrosterone + sulfate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
granulosa cell luteinized, follicle Homo sapiens
-
ovarian follicle luteinized granulosa cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dehydroepiandrosterone sulfate + H2O
-
Homo sapiens dehydroepiandrosterone + sulfate
-
?
dehydroepiandrosterone sulfate + H2O oestrogen biosynthesis Homo sapiens dehydroepiandrosterone + sulfate
-
?

Synonyms

Synonyms Comment Organism
steroid sulphatase
-
Homo sapiens